HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2245293Generated: October 29, 2026
1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 11281010, compound
https://huagongshe.com/reaction/2245293
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene | HCID 2733265 | — |
| Reactant | HCID 59216592 | HCID 59216592 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 11281010 | HCID 11281010 | — |
Reaction Steps
A mixture of 5-amino-1-methyl-1,2,3,4-tetrahydroquinolin-3-ol and 4-chloro-3-trifluoromethyl-phenyl isocyanate in tetrahydrofuran is stirred at 50° C. for 5 hours. After removing the solvent, the resulting residue is purified by silica gel column chromatography to provide N-[4-chloro-3-(trifluoromethyl)phenyl]-N′-(3-hydroxy-1-methyl-1,2,3,4-tetrahydroquinolin-5-yl)urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07683076B2 |
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| Source dataset | uspto-grants-2010_03 |
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| ORD ID | ord-de749950b75445c481b34a0b419f1692 |
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| Source note | uspto-grants-2010_03 |
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