Sodium Carbonate → HCID 86605587, compound

Participants

Reaction Steps

3-Butyl-1-phenethyl-piperidine-4-one (300 mg), NaOAc (878 mg) and hydroxylamine hydrochloride (708 mg) were suspended in ethanol/water (1:1, 10 ml) and the mixture was heated to reflux for 5 hours. The clear solution that resulted from this treatment was cooled, diluted with water and basified with 10% aq. Na2CO3 to pH 10. The suspension was extracted with DCM and the organic layer was washed with brine, dried (MgSO4) and evaporated. The product was sufficiently pure for the next step. Yellowish glass, mixture of cis and trans diastereomers (332 mg). MS (ESI): 261.4 (MH+).

Provenance & Evidence