Sodium Bicarbonate → HCID 68686909, compound

Participants

Reaction Steps

3-Butyl-1-phenethyl-piperidine-4-one oxime (218 mg) was dissolved in THF (10 ml) and LAH (261 mg) was added in one portion. The suspension was then allowed to stir at RT for 24 hours. The reaction mixture was carefully pipetted onto 5% aq. NaHCO3 solution and the aqueous layer was extracted with DCM. The organic layer was washed with brine, dried (MgSO4) and evaporated to give a colorless oil. This was purified by flash chromatography (gradient of MeOH in DCM containing 1% NH4OH) to give the product as cis and trans diastereomers (cis: 127 mg; trans: 36 mg). MS (ESI): 261.4 (MH+).

Provenance & Evidence