Phenethyl bromide → HCID 68688164, compound

HRID 2245348Notes

Reaction equation

HRID 2245348 reaction equation
CO[C:3]([C@@H:5]1[C@H:10]([NH2:11])[CH2:9][CH2:8][N:7]([C:12](OC(C)(C)C)=O)[CH2:6]1)=[O:4].[S:19]1[CH2:23][CH2:22][NH:21][CH2:20]1.BrC[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[NH2:11][C@@H:10]1[CH2:9][CH2:8][N:7]([CH2:12][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:6][C@@H:5]1[C:3]([N:21]1[CH2:22][CH2:23][S:19][CH2:20]1)=[O:4]

Participants

4

Reactant 3

HCID 7666Phenethyl bromideHCID 10444ThiazolidineHCID 58745510HCID 58745510, compound

Product 1

HCID 68688164HCID 68688164, compound

Procedure

This material was obtained as described in example 34 from the opposite enantiomer (3S, 4R)-4-amino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester, thiazolidine and 2-(bromoethyl)-benzene. Yellow oil. MS (ESI): 320.4 (MH+).

Workup

  1. customThis material was obtained

Sources & evidence

ORD record
ord-ecdbd1332605477a8d8d27ac86b5c332
Source dataset
uspto-grants-2010_03
Patent number
US07683079B2

Reaction notes

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