Lithium Hydroxide → HCID 68686898, compound

Participants

Reaction Steps

To a solution of rac-4-tert-butoxycarbonylamino-1-(3,4-dimethoxy-phenyl)-piperidine-3-carboxylic acid ethyl ester (170 mg) in 2 ml THF, were added 1 ml NaOH 1M and lithium hydroxide (100 mg). The suspension was stirred 22 h at RT., diluted with water and extracted twice with tert-butylmethylether. The aqueous layer was acidified to pH 4, saturated with NaCl and then the product was extracted with 3 portions of AcOEt. The organic layers were dried over MgSO4, filtered, evaporated and chromatographed (silica gel, AcOEt) to provide the title compound (38 mg, 55%).

Provenance & Evidence