Sodium Methoxide → HCID 178474508, compound

Participants

Reaction Steps

A solution of Example 5 (2.0 g, 6.4 mmol) and sodium methoxide (25% wt/wt, 32.02 mmol) in methanol (25 mL) was heated to 50° C. for two hours. The mixture was concentrated to dryness under reduced pressure, diluted with DCM (300 mL), and washed with water (200 mL) and brine (200 mL). The organic phase was dried over sodium sulfate, filtered and concentrated to dryness under reduced pressure. The residue was purified by column chromatography using mixture DCM-MeOH (95:5) as eluant to provide the titled compound. 1H NMR (CDCl3) δ ppm 2.24 (3H), 2.32 (3H), 6.75 (1H), 7.05-7.35 (3H); MS (ESI) 313 (M+H).

Provenance & Evidence