Triethylamine → HCID 24853066, compound

Participants

Reaction Conditions

Reaction Steps

The imine (Example 26A, 30 mg, 0.09 mmol) was dissolved in acetonitrile (1.5 mL). Triethylamine (19 μl, 0.18 mmol) was added followed by the 1-piperidinecarbonyl chloride (0.11 mmol). The reaction was heated at 65° C. overnight. The reaction mixture was cooled down and passed through a Si-amine cartridge (1 g, 1.6 mmol/g) to remove the excess carbamyl chloride eluting with additional acetonitrile. The resulting solution was dried and purified by reverse phase HPLC to supply the titled compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 1.40 (4H), 1.53 (2H), 2.20 (3H), 3.43 (4H), 7.24 (1H), 7.63 (2H), 7.83 (1H); MS (ESI) m/z 432.2 (M+H)+.

Provenance & Evidence