2-Methylpyrrolidine → HCID 87464554, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-({[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methylene-1,3-thiazolidin-2-ylidene]amino}carbonyl)-3-methyl-1H-imidazol-3-ium iodide (Example 116, 0.1 g, 0.19 mmol) and 2-methylpyrrolidine (0.018 g, 0.19 mmol) in anhydrous acetonitrile (5 mL) was added Hunig's base (0.025 g), and then the solution was heated at 60° C. for 3 hours. After cooling to room temperature, the reaction was diluted with 50 mL of CH2Cl2, washed water and brine, dried over sodium sulfate, and evaporated under reduced pressure. The crude residue was choromatographed over silica using CH2Cl2 to give the titled compound. 1H NMR (CD3OD) δ ppm 1.00 (3H), 1.60 (1H), 1.90 (3H), 3.40 (2H), 3.90 (1H), 4.80 (2H), 5.20 (1H), 5.35 (1H), 7.30 (2H), 7.50 (1H); MS (ESI) 382(M+H)+.

Provenance & Evidence