反应详情

To a solution of diethyl 1-(bromoacetyl)-2,2-pyrrolidinedicarboxylate (D64, 950 mg) in acetonitrile (10 mL) at r.t, benzylamine (340 microL) was added. The resulting mixture was stirred at r.t. for 3.5 hours: the formation of a white solid was observed. The suspension was then filtered over a Gooch funnel. The organic filtrate was diluted with ethyl acetate (15 mL) and washed with water (2×10 mL). The organic phase was dried and concentrated in vacuo to a residue which was purified by flash chromatography (Cycl/EtOAc from 50/50 to 35:65) to give the desired compound (200 mg) as colourless oil.

1. filtrationThe suspension was then filtered over a Gooch funnel
2. additionThe organic filtrate was diluted with ethyl acetate (15 mL)
3. washwashed with water (2×10 mL)
4. customThe organic phase was dried
5. concentrationconcentrated in vacuo to a residue which
6. customwas purified by flash chromatography (Cycl/EtOAc from 50/50 to 35:65)