HCID 59215830, compound → HCID 59215892, compound

Participants

Reaction Conditions

Reaction Steps

The solution of diethyl {(2R)-2-[({[(phenylmethyl)oxy]carbonyl}amino)methyl]-1-pyrrolidinyl}propanedioate (D110, 1.07 g, 2.72 mmol) in EtOH (ca. 20 ml) was degassed, (10%) Pd/C (580 mg) was added and the reaction mixture was stirred under a H2 atmosphere for 2.5 hrs. The catalyst was filtered off and the volume of the filtrated solution was reduced in vacuo. The solution was warmed-up to 50° C. and it was stirred at this temperature for 6 hrs and at room temperature for 12 hrs. The solvent was evaporated to dryness to give the title compound (617 mg) as a mixture of diastereoisomers (ratio ca. 70:30). This crude was used in the next step without further purification.

Provenance & Evidence