Hydrochloric Acid → HCID 16063831, compound

Participants

Reaction Steps

To a solution of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (E34) (300 mg, 0.449 mmol) in 2 mL of diethyl ether was added 0.6 mL of a 1M HCl solution in diethyl ether. A white precipitate formed. The solvent and excess HCl were removed under a stream of nitrogen and the residue was triturated with 1 mL of 1:1 pentane: Et2O. The white solid was collected by filtration and left under high vacuum to give the title compound 280 mg, 0.397 mmol, 88% yield.

Provenance & Evidence