HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(5-fluoro-2-methylphenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(5-fluoro-2-methylphenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide | HCID 16063913 | — |
| Product | 2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(5-fluoro-2-methylphenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide hydrochloride | HCID 16063948 | — |
Reaction Steps
HCl salt made according to method described in Example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(5-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (E45, 11.5 mg) to afford a pale yellow solid
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07683056B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-63f05b71d77046cbad3af182cf841ab4 |
| Source note | uspto-grants-2010_03 |