Hydrochloric Acid → 2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(2-chloro-4-fluorophenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide

Participants

Reaction Conditions

Reaction Steps

2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(2-chloro-4-fluorophenyl)-6-[(7S,9aS)-7-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)hexahydropyrazino[2,1-c][1,4]oxazin -8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (D58, 22 mg, 0.027 mmol) was dissolved in dry MeOH (2 mL), cooled in an ice-salt bath to ˜0° C. before adding c.HCl solution (˜0.1 mL), slowly. The reaction mixture was stirred at ˜0° C. for 1 hour before warming up and stirring at R.T. for 2 hours. Placed directly onto a 2 g SCX column, washing with MeOH (2×5 mL) before eluting the compound off with NH3 in MeOH (4×5 mL). Solvent evaporated under reduced pressure to afford the title compound as an off white solid. (10mg)

Provenance & Evidence