HCID 68541566, compound → HCID 16113774, compound

HRID 2245507Notes

Reaction equation

HRID 2245507 reaction equation
COC(=O)COC1C=CC(CN2C3C(=CC(N)=CC=3)C=C2)=CC=1.[CH3:24][O:25][C:26](=[O:61])[CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][N:36]2[C:44]3[C:39](=[CH:40][C:41]([NH:45][S:46]([C:49]4[CH:54]=[CH:53][C:52]([C:55]5[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=5)=[CH:51][CH:50]=4)(=[O:48])=[O:47])=[CH:42][CH:43]=3)[CH:38]=[CH:37]2)=[CH:31][CH:30]=1>>[CH3:24][O:25][C:26](=[O:61])[CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][N:36]2[C:44]3[C:39](=[CH:40][C:41]([NH:45][S:46]([C:49]4[CH:54]=[CH:53][C:52]([C:55]5[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=5)=[CH:51][CH:50]=4)(=[O:48])=[O:47])=[CH:42][CH:43]=3)[CH:38]=[CH:37]2)=[CH:31][CH:30]=1.[C:52]1([C:55]2[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=2)[CH:51]=[CH:50][C:49]([S:46]([NH:45][C:41]2[CH:40]=[C:39]3[C:44](=[CH:43][CH:42]=2)[N:36]([CH2:35][C:32]2[CH:33]=[CH:34][C:29]([O:28][CH2:27][C:26]([OH:61])=[O:25])=[CH:30][CH:31]=2)[CH:37]=[CH:38]3)(=[O:48])=[O:47])=[CH:54][CH:53]=1

Participants

4

Reactant 2

HCID 68541566HCID 68541566, compoundHCID 68545374HCID 68545374, compound

Product 2

HCID 16113774HCID 16113774, compoundHCID 68545374HCID 68545374, compound

Procedure

{4-[5-(Biphenyl-4-sulfonylamino)-indol-1-ylmethyl]-phenoxy}-acetic acid methyl ester was prepared from [4-(5-amino-indol-1-ylmethyl)-phenoxy]-acetic acid methyl ester following the procedure of Example 2 Step 1. The title compound was prepared from {4-[5-(biphenyl-4-sulfonylamino)-indol-1-ylmethyl]-phenoxy}-acetic acid methyl ester following the procedure of Example 2 Step 3: MS (ESI) m/z 513, MS (ESI) m/z 511.

Sources & evidence

ORD record
ord-1fa59d9f396e496f91f5062ba574921a
Source dataset
uspto-grants-2010_03
Patent number
US07683091B2

Reaction notes

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