HCID 68541566, compound → HCID 16113773, compound

HRID 2245508Notes

Reaction equation

HRID 2245508 reaction equation
COC(=O)COC1C=CC(CN2C3C(=CC(N)=CC=3)C=C2)=CC=1.[CH3:24][O:25][C:26](=[O:59])[CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][N:36]2[C:44]3[C:39](=[CH:40][C:41]([NH:45][S:46]([C:49]4[CH:54]=[CH:53][C:52]([C:55]([CH3:58])([CH3:57])[CH3:56])=[CH:51][CH:50]=4)(=[O:48])=[O:47])=[CH:42][CH:43]=3)[CH:38]=[CH:37]2)=[CH:31][CH:30]=1>>[CH3:24][O:25][C:26](=[O:59])[CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][N:36]2[C:44]3[C:39](=[CH:40][C:41]([NH:45][S:46]([C:49]4[CH:50]=[CH:51][C:52]([C:55]([CH3:57])([CH3:56])[CH3:58])=[CH:53][CH:54]=4)(=[O:48])=[O:47])=[CH:42][CH:43]=3)[CH:38]=[CH:37]2)=[CH:31][CH:30]=1.[C:55]([C:52]1[CH:51]=[CH:50][C:49]([S:46]([NH:45][C:41]2[CH:40]=[C:39]3[C:44](=[CH:43][CH:42]=2)[N:36]([CH2:35][C:32]2[CH:31]=[CH:30][C:29]([O:28][CH2:27][C:26]([OH:59])=[O:25])=[CH:34][CH:33]=2)[CH:37]=[CH:38]3)(=[O:47])=[O:48])=[CH:54][CH:53]=1)([CH3:58])([CH3:56])[CH3:57]

Participants

4

Reactant 2

HCID 68541566HCID 68541566, compoundHCID 68549113HCID 68549113, compound

Product 2

HCID 16113773HCID 16113773, compoundHCID 68549113HCID 68549113, compound

Procedure

{4-[5-(4-tert-butyl-benzenesulfonylamino)-indol-1-ylmethyl]-phenoxy}-acetic acid methyl ester was prepared from [4-(5-amino-indol-1-ylmethyl)-phenoxy]-acetic acid methyl ester following the procedure of Example 2 Step 1. The title compound was prepared from {4-[(5-{[(4-tert-butylphenyl)sulfonyl]amino}-1H-indol-1-yl)methyl]phenoxy}acetic acid methyl ester following the procedure of Example 2 Step 3: MS (ESI) m/z 493, MS (ESI) m/z 491.

Sources & evidence

ORD record
ord-b97989de76a24418b0afaf5e8f06f6ef
Source dataset
uspto-grants-2010_03
Patent number
US07683091B2

Reaction notes

Loading…