Benzenesulfonyl chloride → HCID 16113986, compound

HRID 2245511Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH:11]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:12]([NH:14][NH2:15])=[O:13])[CH:6]=[CH:5]2.[F:23][C:24]([F:37])([F:36])[O:25][C:26]1[CH:31]=[CH:30][C:29]([S:32](Cl)(=[O:34])=[O:33])=[CH:28][CH:27]=1.C1(S(Cl)(=O)=O)C=CC=CC=1>>[NH:14]([C:12]([CH:11]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][S:32]([C:29]3[CH:28]=[CH:27][C:26]([O:25][C:24]([F:23])([F:36])[F:37])=[CH:31][CH:30]=3)(=[O:34])=[O:33])=[CH:10][CH:9]=2)[CH:5]=[CH:6]1)[CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:13])[NH2:15]

Participants

Reactant 3

HCID 7369Benzenesulfonyl chloride

HCID 523102p-(Trifluoromethoxy)benzenesulphonyl chloride

HCID 68546540HCID 68546540, compound

Product 1

HCID 16113986HCID 16113986, compound

Procedure

N-[1-(1-Hydrazinocarbonyl-2-phenyl-ethyl)-1H-indol-5-yl]-4-trifluoromethoxy-benzenesulfonamide was prepared from 2-(5-amino-indol-1-yl)-3-phenyl-propionic acid hydrazide following the procedure of Example 2 Step 1 substituting 4-trifluoro methoxy-benzene sulfonyl chloride for benzenesulfonyl chloride: MS (ESI) m/z 519, MS (ESI) m/z 517.

Sources & evidence

ORD record: ord-c05cad4230c64704ab238f387edb246e
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07683091B2

Reaction notes

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