2-Oxindole-6-carbonitrile → HCID 135481030, compound

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Reaction Steps

Starting materials: 2-oxoindoline-6-carbonitrile (added at 5-10° C.) and (2-{4-[(6-chloropyridin-3-yl)sulfonyl]piperazin-1-yl}ethyl)-N,N-dimethylamine. Yield: 8%: 1H NMR (D2O, 400 MHz) δ 8.19 (s, 1H), 7.74 (d, J=9 Hz, 1H), 7.28 (d, J=9 Hz, 1H), 7.20 (s, 1H), 7.03 (s, 1H), 3.43 (t, J=7 Hz, 2H), 3.34 (m, 4H), 3.20 (t, J=7 Hz, 2H), 3.09 (m, 4H), 2.90 (s, 6H); MS (ES) m/z 455 (M++1).

Provenance & Evidence