4-(6-chloro-pyridine-3-sulfonyl)-morpholine → HCID 136338437, compound

HRID 2245573Notes

Reaction equation

HRID 2245573 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:17][O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][CH:32]=1)[NH:29][C:28](=[O:33])[CH2:27]2)=[O:23]>>[ClH:1].[OH:33][C:28]1[NH:29][C:30]2[C:26]([C:27]=1[C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)(=[O:10])=[O:9])=[CH:6][N:7]=1)=[CH:25][C:24]([C:22]([NH:21][CH2:20][CH2:19][O:18][CH3:17])=[O:23])=[CH:32][CH:31]=2

Participants

3

Reactant 2

HCID 2741474-(6-chloro-pyridine-3-sulfonyl)-morpholineHCID 68544478HCID 68544478, compound

Product 1

HCID 136338437HCID 136338437, compoundYield 7%

Procedure

Starting materials: 4-[(6-chloropyridin-3-yl)sulfonyl]morpholine and N-(2-methoxyethyl)-2-oxoindoline-5-carboxamide. Yield: 7%: 1H NMR (DMSO-d, 400 MHz) δ 10.85 (s, 1H), 8.45 (m, 2H), 7.99 (s, 1H), 7.74 (s, 2H), 7.58 (m, 1H), 6.94 (d, J=8 Hz, 1H), 3.65 (m, 4H), 3.45 (m, 4H), 3.27 (s, 3H), 3.00 (m, 4H); MS (ES) m/z 461 (M++1).

Sources & evidence

ORD record
ord-4483edfdd88b44cc82886dac93589656
Source dataset
uspto-grants-2010_03
Patent number
US07683067B2

Reaction notes

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