Sodium bis(trimethylsilyl)amide → HCID 135476514, compound

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Reaction Steps

The title compound was prepared as described for Example 117. Starting material: 1-[(6-chloro-1-oxidopyridin-3-yl)methyl]piperidine (0.136 g, 0.60 mmol) and 2-oxoindoline-6-carbonitrile (0.100 g, 0.63 mmol) and sodium bis(trimethylsilyl)amide (1.4 mL, 1.4 mmol). Yield: 0.031 g, 12%: 1H NMR D2O, 400 MHz) δ 8.01 (d, J=2 Hz, 1H), 7.75 (dd, J=9, 2 Hz, 1H), 7.28 (d, J=9 Hz, 1H), 7.06 (m, 2H), 6.92 (s, 1H), 4.19 (s, 2H), 3.53 (m, 2H), 2.98 (m, 2H), 1.94 (s, 2H), 1.82 (m, 1H), 1.70 (m, 2H), 1.46 (m, 1H); MS (ESP) m/z 349 (M++1).

Provenance & Evidence