Cesium carbonate → 3-{6-[2-(Diisopropylamino)ethoxy]pyrimidin-4-yl}-2-hydroxy-1H-indole-6-carbonitrile hydrochloride

Participants

Reaction Steps

The title compound was prepared as described for Example 120 using N-{2-[(6-chloropyrimidin-4-yl)oxy]ethyl}-N-isopropylpropan-2-amine (0.10 g, 0.39 mmol), 2-oxoindoline-6-carbonitrile (0.074 g, 0.47 mmol) and cesium carbonate (0.50 g, 1.54 mmol). Yield 0.026 g, 15%: 1H NMR (CD3OD, 400 MHz) δ 8.59 (s, 1H), 7.81 (d, J=8 Hz, 1H), 7.55 (d, J=1 Hz, 1H), 7.45 (dd, J=8, 1 Hz, 1H), 6.64 (s, 1H), 4.40 (t, J=6 Hz, 1H), 3.87 (m, 1H), 3.58 (t, J=6 Hz, 1H), 1.44 (m, 3H); MS (ESP) m/z 380 (M++1).

Provenance & Evidence