反应详情

温度

50 °C

4.5 g of N-(1-Phenyl-cyclohexylmethyl)-acetamide were dissolved in 80 ml of methylenechloride and 3.8 ml of chlorosulfonic acid were added. The reaction mixture was stirred at 50° C. for 10 hours and was poured on ice water. The organic layer was separated, washed twice with 50 ml brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 1.5 g of a light yellow oil.

1. additionwas poured on ice water
2. customThe organic layer was separated
3. washwashed twice with 50 ml brine
4. dry with materialdried over MgSO4
5. customThe solvent was removed in vacuo