Chlorosulfonic acid → HCID 59216854, compound

HRID 2245631Notes

Reaction equation

HRID 2245631 reaction equation
[C:1]1([C:7]2([CH2:13][NH:14][C:15](=[O:17])[CH3:16])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:18][S:19](O)(=[O:21])=[O:20]>C(Cl)Cl>[C:15]([NH:14][CH2:13][C:7]1([C:1]2[CH:6]=[CH:5][C:4]([S:19]([Cl:18])(=[O:21])=[O:20])=[CH:3][CH:2]=2)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)(=[O:17])[CH3:16]

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 68617682HCID 68617682, compound

Product 1

HCID 59216854HCID 59216854, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

4.5 g of N-(1-Phenyl-cyclohexylmethyl)-acetamide were dissolved in 80 ml of methylenechloride and 3.8 ml of chlorosulfonic acid were added. The reaction mixture was stirred at 50° C. for 10 hours and was poured on ice water. The organic layer was separated, washed twice with 50 ml brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 1.5 g of a light yellow oil.

Workup

  1. additionwas poured on ice water
  2. customThe organic layer was separated
  3. washwashed twice with 50 ml brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-d19630a77d654412910e6ea750fd4e8d
Source dataset
uspto-grants-2010_03
Patent number
US07683181B2

Reaction notes

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