Pyridine → HCID 59216848, compound

HRID 2245632Notes

Reaction equation

HRID 2245632 reaction equation
[S:1]1[CH:5]=[N:4][N:3]=[C:2]1[NH2:6].[C:7]([NH:10][CH2:11][C:12]1([C:18]2[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)(=[O:9])[CH3:8].N1C=C[CH:31]=[CH:30][CH:29]=1>>[CH:30]([C:5]1[S:1][C:2]([NH:6][S:24]([C:21]2[CH:22]=[CH:23][C:18]([C:12]3([CH2:11][NH:10][C:7](=[O:9])[CH3:8])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)=[CH:19][CH:20]=2)(=[O:26])=[O:25])=[N:3][N:4]=1)([CH3:31])[CH3:29]

Participants

4

Reactant 3

HCID 1049PyridineHCID 199091,3,4-Thiadiazol-2-amineHCID 59216854HCID 59216854, compound

Product 1

HCID 59216848HCID 59216848, compound

Procedure

600 mg of 5-isopropyl-(1,3,4-thiadiazol-2-ylamine were dissolved in 2 ml of pyridine. 1400 mg of 4-[1-(acetylamino-methyl)-cyclohexyl]-benzenesulfonyl chloride were added and the reaction mixture was stirred at room temperature for 15 hours. The pyridine was removed in vacuo and the residue coevaporated three times with portions of 100 ml toluene. The residue was purified by chromatography on silica gel with the eluents dichloromethane:methanol=95:5 to obtain 1.0 g of a light yellow oil.

Workup

  1. customThe pyridine was removed in vacuo
  2. customThe residue was purified by chromatography on silica gel with the eluents dichloromethane

Sources & evidence

ORD record
ord-24d578250adc426aa3949425725931ac
Source dataset
uspto-grants-2010_03
Patent number
US07683181B2

Reaction notes

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