Acetic Acid → HCID 12876546, compound

HRID 224582Notes

Reaction equation

HRID 224582 reaction equation
[NH2:1][C:2]1[C:3](=[O:17])[N:4]([CH2:14][CH2:15][CH3:16])[C:5](=[O:13])[N:6]([CH2:9][CH:10]([OH:12])[CH3:11])[C:7]=1[NH2:8].[C:18](O)(=O)[CH3:19]>>[OH:12][CH:10]([CH3:11])[CH2:9][N:6]1[C:7]2[N:8]=[C:18]([CH3:19])[NH:1][C:2]=2[C:3](=[O:17])[N:4]([CH2:14][CH2:15][CH3:16])[C:5]1=[O:13]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 12876545HCID 12876545, compound

Product 1

HCID 12876546HCID 12876546, compound

Procedure

About 15 g of 5,6-diamino-1-(2-hydroxypropyl)-3-propyl-2,4-(1H, 3H)-pyrimidinedione as an oil was refluxed for one hour in 50 ml of acetic acid. The solution was evaporated and the residue was dissolved in water. Active carbon was added and filtered off. To the filtrate 25 ml of 5-N NaOH was added and the solution was refluxed for 30 minutes. Hydrochloric acid was added until acid reaction and the received crystals were filtered off and recrystallized from 200 ml of water. Yield 2.7 g. NMR.

Workup

  1. customThe solution was evaporated
  2. dissolutionthe residue was dissolved in water
  3. additionActive carbon was added
  4. filtrationfiltered off
  5. additionTo the filtrate 25 ml of 5-N NaOH was added
  6. temperaturethe solution was refluxed for 30 minutes
  7. additionHydrochloric acid was added until acid reaction
  8. filtrationthe received crystals were filtered off
  9. customrecrystallized from 200 ml of water

Sources & evidence

ORD record
ord-303182d790b4458c95be689c0a3ee8b4
Source dataset
uspto-grants-1980_11
Patent number
US04233303

Reaction notes

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