Tetrahydrofuran → HCID 24804444, compound

Participants

Reaction Conditions

Reaction Steps

A 25 mL scintillation vial was charged with 5-[3-(4-tert-butyl-benzenesulfonylamino)-5-chloro-pyridin-2-yl]-4-isopropyl-4H-[1,2,4]triazole-3-carboxylic acid ethyl ester (prepared according to general procedure B, 11 mg, 0.02 mmol), methylmagnesium bromide in THF (0.2 mL, 3.0 M), and tetrahydrofuran (3 mL). The vial was sealed and stirred at 0° C. for 2 h. The volatiles were then evacuated in vacuo and the residue was purified via preparatory HPLC to afford 4-tert-butyl-N-{5-chloro-2-[5-(1-hydroxy-1-methyl-ethyl)-4-isopropyl-4H-[1,2,4]triazol-3-yl]-pyridin-3-yl}-benzenesulfonamide as a white powder: MS (ES) M+H expected 492.2, found 492.5.

Provenance & Evidence