Acetonitrile → HCID 59216808, compound

HRID 2245848Notes

Reaction equation

HRID 2245848 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[C:13]([C:19]([NH:21][NH2:22])=O)=[N:14][CH:15]=[C:16]([Cl:18])[CH:17]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[C:23]([F:26])([F:25])[F:24].[CH3:27]OC(OC)OC.C(#N)C.[O:37]([C:39]1[CH:45]=[CH:44][C:43]([F:46])=[CH:42][C:40]=1[NH2:41])[CH3:38]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[C:13]([C:19]3[N:41]([C:40]4[CH:42]=[C:43]([F:46])[CH:44]=[CH:45][C:39]=4[O:37][CH3:38])[CH:27]=[N:22][N:21]=3)=[N:14][CH:15]=[C:16]([Cl:18])[CH:17]=2)(=[O:9])=[O:10])=[CH:4][C:3]=1[C:23]([F:24])([F:26])[F:25]

Participants

6

Reactant 4

HCID 6342AcetonitrileHCID 9005Trimethyl orthoformateHCID 2231055-Fluoro-2-methoxyanilineHCID 59216810HCID 59216810, compound

Product 1

HCID 59216808HCID 59216808, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared according to general Method B using 4-Chloro-N-(5-chloro-2-hydrazinocarbonyl-pyridin-3-yl)-3-trifluoromethyl-benzenesulfonamide (100 mg, 0.234 mmol), trimethylorthoformate (80 mg, 0.60 mmol), acetonitrile (2 mL), 2-methoxyl-5-fluoroaniline (70 mg, 0.50 mmol) and acetic acid (1.0 mL). MS (ES) [M+H]+ expected 562.0, found 562.0.

Sources & evidence

ORD record
ord-0948433ee2574c5cbebb264b77d0e563
Source dataset
uspto-grants-2010_03
Patent number
US07683176B2

Reaction notes

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