Sodium Carbonate → HCID 68695725, compound

Participants

Reaction Steps

Sodium carbonate (2.12 g) was added to the solution of homopiperazine (10.0 g; 5 eq.) and ethyl 4-bromobutyrate (3.90 g; 1 eq.) in CH3CN (120 mL). The reaction was stirred at room temperature for 6 h. The reaction mixture was filtered thru a celite pad. The filtrate was concentrated. The remaining residual was dissolved in CHCl3 (120 mL), washed by H2O (50 mL×3) and brine (50 mL×1), dried by Na2SO4 and concentrated to give 4-[1,4]diazepan-1-yl-butyric acid ethyl ester (3.8 g), which was carried on for the next step without further purification.

Provenance & Evidence