Benzaldehyde → HCID 12003998, compound

Participants

Reaction Steps

The title compound was made by a procedure identical to that of Example 66 with 1.50 g of (4-{3-[(R)-((2S,5R)-2,5-dimethyl-piperazin-1-yl)-(3-hydroxy-phenyl)-methyl]-benzoyl}-piperazin-1-yl)-acetic acid ethyl ester (3.03 mmol) and 0.64 g of benzaldehyde (6.07 mmol) to give 0.61 g (34%) of the desired compound as a light yellow solid. 1H NMR (300 MHz, d6-DMSO): □ 1.00-1.02 (d, J=4.7 Hz, 6H); 1.15-1.19 (t, 3H), 1.87-2.00 (m, 2H); 2.48-2.65 (m, 8H); 3.25 (s, 2H); 3.36-3.57 (m, 5H); 3.73-3.77 (dd, 1H); 4.03-4.10 (q, 2H); 4.96 (s, 1H); 6.62-6.69 (m, 3H); 7.08-7.42 (m, 10H); 9.35 (s, 1H). Calculated for C35H44N4O4.0.16 CH2Cl2: C, 70.58; H, 7.47; N, 9.36. Found: C, 70.57; H, 7.52; N, 9.39.

Provenance & Evidence