4-(3-(Trifluoromethyl)phenyl)-1-piperazineethanol → 2-[4-(3-Trifluoromethylphenyl)-piperazin-1-yl]-ethyl 2-(7-chloro-4-quinolinylamino)-5-fluoro-benzoate

Participants

Reaction Steps

Using the procedure of Example 3, 4 g of the ester of Example 1 and 3.316 g of 2-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]-ethanol were reacted to obtain 6.88 g of a raw oily product. 500 mg of the said product were crystallized from isopropyl ether to obtain 425 mg of 2-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]-ethyl 2-(7-chloro-4-quinolinylamino)-5-fluoro-benzoate melting at 113° C.

Provenance & Evidence