Tetrafluoroboric acid → HCID 86611024, compound

Participants

Reaction Steps

To a solution of 1-chloro-4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranos-1-yl)-2-[4-(1-hydroxymethyl-cyclopent-1-yloxy)-benzyl]-benzene (0.56 g) in dichloromethane (4 mL) chilled in an ice-bath is added tetrafluoroboric acid (0.12 mL) and trimethylsilyldiazomethane (0.45 mL). The solution is stirred at ambient temperature for 1 h and then quenched with water. The resultant mixture is extracted with dichloromethane, the combined extracts are dried (Na2SO4), the solvent is removed and the residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 1:0→2:1).

Provenance & Evidence