Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 58597012 | HCID 58597012 | — |
| Reactant | 1-Chloro-4-(beta-glucopyranos-1-yl)-2-(4-hydroxybenzyl)-benzene | HCID 86600674 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86611026 | HCID 86611026 | — |
Reaction Steps
A mixture of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-(4-hydroxybenzyl)-benzene (0.25 g), 3-hydroxy-cyclopent-1-yl p-tolylsulfonate (0.19 g) and cesium carbonate (0.33 g) in dimethylformamide (1.5 mL) is stirred at 70° C. for 16 h. After cooling to ambient temperature, water is added and the resultant mixture is extracted with ethyl acetate. The combined organic phases are dried (Na2SO4), the solvent is removed and the residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0→4:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07683160B2 |
|---|
| Source dataset | uspto-grants-2010_03 |
|---|
| ORD ID | ord-661143650a344a7e81672257f4ce2257 |
|---|
| Source note | uspto-grants-2010_03 |
|---|
