2-(Dimethylamino)ethanol → 2-Dimethylamino-ethyl 2-(8-chloro-4-quinolinylamino)-5-fluoro-benzoate

Beteiligte Stoffe

Reaktionsschritte

Using the procedure of Step B of Example 7, 6.61 g of the product of Step A and 4 ml of anhydrous 2-dimethylamino-ethanol were reacted to obtain 6.8 g of 2-dimethylamino-ethyl 2-(8-chloro-4-quinolinylamino)-5-fluoro-benzoate melting at 121°-122° C. 5.245 g of the said product were dissolved in 10 ml of anhydrous ethanol and 2.05 ml of an ethanol solution of 6.6 N hydrochloric acid were added thereto. The mixture was ice cooled and was vacuum filtered and the recovered product was washed with a 1-4 ethanol-ether mixture to obtain 5.34 g of the desired hydrochloride melting at 198° C.

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