Hydrazine hydrate (1:1) → Methyl 4-(3-hydrazino-1,2,4-triazin-6-yl)benzoate

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Reaction Steps

To a solution of methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate (1.1 g, 0.0044 mol) in tetrahydrofuran (30 mL) was added hydrazine hydrate (1.1 mL, 0.022 mol) at RT with stirring. The mixture was stirred at RT for 1 h, and concentrated under reduced pressure to give the desired product (quantitatively). Analytical LCMS: (M+H)+=245.9.

Provenance & Evidence