2-Amino-5-methylthiazole → HCID 54690142, compound

Participants

Reaction Steps

5.2 gm (0.017 mol) of methyl 4-hydroxy-6-methoxy-2-methyl-2H-1,2-benzothiazine-3-caboxylate-1,1-dioxide and 2.2 gm (0.019 mol) of 2-amino-5-methyl-thiazole were refluxed in 200 ml of xylene for 24 hours. After cooling, the precipitated crystals were filtered off and recrystallized from tetrahydrofuran. 5.8 gm (89% of theory) of 4-hydroxy-6-methoxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-caboxamide-1,1-dioxide were obtained.

Provenance & Evidence