Estradiol → 19-Hydroxytestosterone

HRID 2246035Notes

Reaction equation

[CH3:1][C@@:2]12[C@@H:10]([OH:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH2:13][C:14]3[C@@:20]([CH3:21])([C@H:5]1[CH2:4][CH2:3]2)[CH2:19][CH2:18][C:16](=[O:17])[CH:15]=3.C[C@@]12[C@@H]([OH:40])CC[C@H]1[C@H]1[C@@H](C3C=CC(O)=CC=3CC1)CC2>>[CH3:1][C@@:2]12[C@@H:10]([OH:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH2:13][C:14]3[C@@:20]([CH2:21][OH:40])([C@H:5]1[CH2:4][CH2:3]2)[CH2:19][CH2:18][C:16](=[O:17])[CH:15]=3

Participants

Reactant 2

HCID 5757Estradiol

HCID 6013Testosterone

Product 1

HCID 15096819-Hydroxytestosterone

Procedure

This compound is the postulated reaction intermediate of the first hydroxylation step of testosterone-to-estradiol conversion by Aromatase.

Sources & evidence

ORD record: ord-8816b3d498b04ebba47cf3d592be9a65
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07687252B2

Reaction notes

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