Hydrochloric Acid → HCID 58899086, compound

Participants

Reaction Steps

6.2 g (0.024 mol) of ethyl 2-amino-3-oxo-3-o-tolylpropionate hydrochloride were dissolved in methylene chloride, and 9.7 g (0.096 mol) of triethylamine were added. At 0° C., 5.4 g (0.024 mol) of 4-fluoro-2-trifluoromethylbenzoyl chloride, dissolved in methylene chloride, were added dropwise. The mixture was stirred at room temperature (RT) for 1 h, and 5% strength hydrochloric acid was then added. The organic phase was separated off, washed and dried, and the solvent was removed. Chromatographic purification (silica gel column, cyclohexane/ethyl acetate) gave 4.7 g of the title compound as colorless crystals.

Provenance & Evidence