Triethylamine → HCID 58899080, compound

Participants

Reaction Steps

1.4 g (0.0052 mol) of methyl 2-amino-3-(N-benzyl-N-formylamino)-3-phenylpropionate were dissolved in methylene chloride, and 1.0 g (0.0052 mol) of 4-fluoro-2-trifluoromethylbenzoic acid and 1.0 g (0.010 mol) of triethylamine in THF were added. At 0-5° C., 1.3 g (0.0052 mol) of bis(2-oxo-3-oxazolidinyl)phosphoryl chloride were added. After 2 h at 0° C., the mixture was stirred at room temperature for 15 h. The solvents were removed and the residue was taken up in ethyl acetate, washed and dried. Chromatographic purification (silica gel column, cyclohexane/ethyl acetate) gave 0.65 g of the title compound as a colorless oil.

Provenance & Evidence