1,1-Dichloroethane → 4-(2-Chloro-5-fluoro-benzoylamino)-3-methoxy-benzoyl chloride

HRID 2246069Notes

Reaction equation

HRID 2246069 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][C:8]=1[O:16][CH3:17])=[O:5].[Cl:23]C(Cl)C>>[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([Cl:23])=[O:12])=[CH:9][C:8]=1[O:16][CH3:17])=[O:5]

Participants

3

Reactant 2

HCID 63651,1-DichloroethaneHCID 592180674-(2-Chloro-5-fluoro-benzoylamino)-3-methoxy-benzoic acid

Product 1

HCID 114619844-(2-Chloro-5-fluoro-benzoylamino)-3-methoxy-benzoyl chloride

Procedure

In a manner analogous to the process outlined in Example 12, 4-(2-chloro-5-fluoro-benzoylamino)-3-methoxy-benzoic acid was suspended in dichloroethane and reacted to yield the 4-(2-chloro-5-fluoro-benzoylamino)-3-methoxy-benzoyl chloride as a white solid.

Workup

  1. customreacted

Sources & evidence

ORD record
ord-f7ac66d4b5db449782333279607db79c
Source dataset
uspto-grants-2010_03
Patent number
US07687494B2

Reaction notes

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