Azetidine-3-carbonitrile hydrochloride → HCID 68601157, compound

HRID 2246084Notes

Reaction equation

HRID 2246084 reaction equation
[C:1]([C:4]1[N:5]=[CH:6][S:7][C:8]=1/[CH:9]=[CH:10]\[S:11][C:12]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(O)=[O:2].Cl.[C:32]([CH:34]1[CH2:37][NH:36][CH2:35]1)#[N:33]>>[C:32]([CH:34]1[CH2:37][N:36]([C:1]([C:4]2[N:5]=[CH:6][S:7][C:8]=2/[CH:9]=[CH:10]\[S:11][C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[O:2])[CH2:35]1)#[N:33]

Participants

3

Reactant 2

HCID 45072465Azetidine-3-carbonitrile hydrochlorideHCID 68601215HCID 68601215, compound

Product 1

HCID 68601157HCID 68601157, compoundYield 72.6%

Procedure

In the same manner as in step c) in Example 3, 716 mg of the title compound was prepared from 859 mg of 4-carboxy-5-((Z)-2-tritylthioethen-1-yl)thiazole and 237 mg of 3-cyanoazetidine hydrochloride.

Sources & evidence

ORD record
ord-daf42a3806c048b988f3f644b1a1ce8e
Source dataset
uspto-grants-2010_03
Patent number
US07687490B2

Reaction notes

Loading…