Isopropanol → HCID 70592898, compound

Participants

Reaction Steps

A mixture of 4.5 g of 1'-[1-(4-benzyloxybenzoyl)ethyl]-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine, 5.6 g of sodium borohydride and 150 ml of isopropylalcohol was refluxed for 1 hour. The resulting mixture was poured into water and was extracted with ethylacetate. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated in vacuo. The crude solid was recrystallized from ethanol to give 1'-[1-(4-benzyloxyphenyl)-1-hydroxypropane-2-yl]-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine.

Provenance & Evidence