HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl glycidyl ether → 1'-(2-Hydroxy-3-phenoxypropyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl glycidyl ether | HCID 31217 | — |
| Reactant | 1-Methylspiro[indoline-3,4'-piperidin]-2-one | HCID 21584155 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1'-(2-Hydroxy-3-phenoxypropyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine | HCID 70592476 | — |
Reaction Steps
A mixture of 1.7 g of 1-phenoxy-2,3-epoxypropane, 2 g of 1-methyl-2-oxo-indoline-3-spiro-4'-piperidine and 120 ml of ethanol was refluxed for 3 hours. The resulting mixture was concentrated and crystallized from diisopropylether to give 1'-(2-hydroxy-3-phenoxypropyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04233307 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-f009d0cab4cd42a8b14df80ecf9c6b1f |
| Source note | uspto-grants-1980_11 |