反应详情

Pentafluoropyridine (3.4 g; 20 mmol) was dissolved in dichloromethane (50 mL) and chilled in an ice bath. To the solution was added morpholine (3.48 g; 40 mmol) and the reaction was allowed to warm to room temperature with stirring overnight. The organic phase was washed with saturated ammonium chloride solution (2×20 mL), dried over magnesium sulfate, evaporated, and purified by column chromatography to give 4-(2,3,5,6-tetrafluoro-pyridin-4-yl)-morpholine.

1. temperaturechilled in an ice bath
2. washThe organic phase was washed with saturated ammonium chloride solution (2×20 mL)
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. custompurified by column chromatography