反应详情

Celite (27 g, oven dried) and pyridinium chlorochromate (26.46 g; 12.27 mmol) were added to a solution of 2,3-dimethoxy-4-(1′-hydroxypropyl)pyridine (4) (18.6 g; 94.4 mmol) in anhydrous dichloromethane (300 mL). The resultant mixture was stirred at room temperature for 16 hours. The mixture was then filtered through a pad of Celite and silica gel. Concentration generated 13.8 g of the crude 1-(2,3-dimethoxy-pyridin-4-yl)-propan-1-one (5) product which was utilized in the subsequent synthesis step without further purification.

1. filtrationThe mixture was then filtered through a pad of Celite and silica gel
2. concentrationConcentration
3. customwas utilized in the subsequent synthesis step without further purification