3-Chloro-6-(1-piperazinyl)pyridazine → HCID 60209564, compound

HRID 2246220Notes

Reaction equation

HRID 2246220 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1.C1([O:20][C:21]([O:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=O)C=CC=CC=1>>[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[CH2:9][CH2:10][N:11]([C:21]([O:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[O:20])[CH2:12][CH2:13]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 52949263-Chloro-6-(1-piperazinyl)pyridazineHCID 12094709Ethyl [(phenoxycarbonyl)oxy]acetate

Product 1

HCID 60209564HCID 60209564, compound

Procedure

The process is performed as described in Example 1 (step 1.2.). Starting with 1.60 g (8.05 mmol) of 3-chloro-6-(1-piperazinyl)pyridazine (J. Med. Chem., 18, 2002, 4011-4017) and 1.99 g (8.86 mmol) of ethyl [(phenyloxy-carbonyl)oxy]acetate, prepared in step 1.1. of Example 1, and after chromatography on silica gel, eluting with a 98/2 mixture of dichloromethane and methanol, 1.70 g of product are obtained in the form of a white solid.

Workup

  1. customprepared in step 1.1
  2. washof Example 1, and after chromatography on silica gel, eluting with a 98/2 mixture of dichloromethane and methanol, 1.70 g of product
  3. customare obtained in the form of a white solid

Sources & evidence

ORD record
ord-fd05c8becdf8404ebe28a998338b0885
Source dataset
uspto-grants-2010_03
Patent number
US07687503B2

Reaction notes

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