Tetrahydrofuran → HCID 68431243, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of the ester from Step C (1 g, 2.11 mmol) in 50 mL of a 4:1 solution of tetrahydrofuran:water at 0° C. was added a solution of lithium hydroxide monohydrate (0.3 g, 6.33 mmol) in 8 mL of water. After stirring at 0° C. for 1 h, the THF was removed by evaporation under reduced pressure and 10 mL of 2N hydrochloric acid was added. The aqueous solution was extracted with three portions of ethyl acetate. The combined organic layers were washed with saturated aqueous brine, dried over sodium sulfate and concentrated in vacuo to afford the product which was used in the next step without purification. LC/MS 360.0 (M+1-BOC).

Provenance & Evidence