Phenol → HCID 11594818, compound

HRID 2246251Notes

Reaction equation

HRID 2246251 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[CH:19]=[N:18][CH:17]=[CH:16][N:15]=1.[C:20]1([OH:26])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[O:26]([C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:13][C:14]1[CH:19]=[N:18][CH:17]=[CH:16][N:15]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 996PhenolHCID 78747AminopyrazineHCID 111738094-Chloro-6-iodoquinazoline

Product 1

HCID 11594818HCID 11594818, compound

Procedure

The compound of Example 4 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, 2-amino-pyrazine and phenol.

Sources & evidence

ORD record
ord-2d5b7fef87684459ac17c6d02fac5b39
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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