Aminopyrazine → HCID 178420798, compound

HRID 2246252Notes

Reaction equation

HRID 2246252 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[CH:19]=[N:18][CH:17]=[CH:16][N:15]=1.[SH:20][C:21]1[N:25]=[CH:24][NH:23][N:22]=1>>[N:23]1[N:22]=[C:21]([S:20][C:9]2[CH:10]=[C:11]3[C:6](=[CH:7][CH:8]=2)[N:5]=[CH:4][N:3]=[C:2]3[NH:13][C:14]2[CH:19]=[N:18][CH:17]=[CH:16][N:15]=2)[NH:25][CH:24]=1

Participants

4

Reactant 3

HCID 78747AminopyrazineHCID 111738094-Chloro-6-iodoquinazolineHCID 178527894HCID 178527894, compound

Product 1

HCID 178420798HCID 178420798, compound

Procedure

The compound of Example 5 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, 2-amino-pyrazine and 3-mercapto-1,2,4-triazole.

Sources & evidence

ORD record
ord-5d335fe6d2b14cc4bff6dc3d125528e8
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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