[1,3]Thiazolo[5,4-b]pyridin-2-amine → HCID 11718100, compound

HRID 2246256Notes

Reaction equation

HRID 2246256 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[N:13]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[S:15][C:14]=1[NH2:22].[SH:23][C:24]1[N:25]([CH3:29])[CH:26]=[CH:27][N:28]=1>>[CH3:29][N:25]1[CH:26]=[CH:27][N:28]=[C:24]1[S:23][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:22][C:14]1[S:15][C:16]2[C:21]([N:13]=1)=[CH:20][CH:19]=[CH:18][N:17]=2

Participants

4

Reactant 3

HCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amineHCID 111738094-Chloro-6-iodoquinazolineHCID 178480602HCID 178480602, compound

Product 1

HCID 11718100HCID 11718100, compound

Procedure

The compound of Example 9 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, thiazolo[5,4-b]pyridin-2-yl-amine and 2-mercapto-1-methyl-imidazole.

Sources & evidence

ORD record
ord-57219a39842747eba8bebc2a6012d4e9
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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