[1,3]Thiazolo[5,4-b]pyridin-2-amine → HCID 11618097, compound

HRID 2246258Notes

Reaction equation

HRID 2246258 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8](F)=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[N:14]1[C:22]2[C:17](=[N:18][CH:19]=[CH:20][CH:21]=2)[S:16][C:15]=1[NH2:23].[SH:24][C:25]1[N:29]([CH3:30])[CH:28]=[N:27][N:26]=1>>[CH3:30][N:29]1[CH:28]=[N:27][N:26]=[C:25]1[S:24][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:23][C:15]1[S:16][C:17]2[C:22]([N:14]=1)=[CH:21][CH:20]=[CH:19][N:18]=2

Participants

4

Reactant 3

HCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amineHCID 219520064-Chloro-7-fluoro-6-iodoquinazolineHCID 178481306HCID 178481306, compound

Product 1

HCID 11618097HCID 11618097, compound

Procedure

The compound of Example 13 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-7-fluoro-6-iodo-quinazoline, thiazolo[5,4-b]-pyridin-2-yl-amine and 3-mercapto-4-methyl-1,2,4-triazole.

Sources & evidence

ORD record
ord-1f43f48e91c149ac8fea3eeb7cf9a039
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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