4-Chloro-6-iodoquinazoline → HCID 23160321, compound

HRID 2246259Notes

Reaction equation

HRID 2246259 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[S:13]1[C:17]2=[N:18][CH:19]=[CH:20][N:21]=[C:16]2[N:15]=[C:14]1[NH2:22].[SH:23][C:24]1[N:28]([CH3:29])[CH:27]=[N:26][N:25]=1>>[CH3:29][N:28]1[CH:27]=[N:26][N:25]=[C:24]1[S:23][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:22][C:14]1[S:13][C:17]2[C:16]([N:15]=1)=[N:21][CH:20]=[CH:19][N:18]=2

Participants

4

Reactant 3

HCID 111738094-Chloro-6-iodoquinazolineHCID 13861644Thiazolo[4,5-b]pyrazin-2-amineHCID 178481306HCID 178481306, compound

Product 1

HCID 23160321HCID 23160321, compound

Procedure

The compound of Example 14 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, thiazolo[5,4-b]-pyrazin-2-yl-amine and 3-mercapto-4-methyl-1,2,4-triazole.

Sources & evidence

ORD record
ord-b6ad6f6165974ed49a351bb66aa03d78
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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