[1,3]Thiazolo[5,4-b]pyridin-2-amine → HCID 178420754, compound

HRID 2246261Notes

Reaction equation

HRID 2246261 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[N:13]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[S:15][C:14]=1[NH2:22].[N:23]1[CH:27]=[C:26]([SH:28])[NH:25][N:24]=1>>[N:23]1[CH:27]=[C:26]([S:28][C:9]2[CH:10]=[C:11]3[C:6](=[CH:7][CH:8]=2)[N:5]=[CH:4][N:3]=[C:2]3[NH:22][C:14]2[S:15][C:16]3[C:21]([N:13]=2)=[CH:20][CH:19]=[CH:18][N:17]=3)[NH:25][N:24]=1

Participants

4

Reactant 3

HCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amineHCID 111738094-Chloro-6-iodoquinazolineHCID 178527741HCID 178527741, compound

Product 1

HCID 178420754HCID 178420754, compound

Procedure

The compound of Example 16 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, thiazolo[5,4-b]pyridin-2-yl-amine and 3H-[1,2,3]triazole-4-thiol.

Sources & evidence

ORD record
ord-8acf1e5cd81e4e0f856bd193239fd265
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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